Interleukin-6 signaling in podocyte hypertrophy
نویسندگان
چکیده
منابع مشابه
Interleukin-6 signaling in podocyte hypertrophy
Diabetic kidney disease is characterized by increased albuminuria associated with structural changes, such as thickening of the glomerular basement membrane, mesangial expansion, and podocyte depletion followed by glomerulosclerosis. Glomerulosclerosis is preceded by early hypertrophic changes in the glomerulus [1]. Among the many characteristic glomerular pathologic changes, a decrease in the ...
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Interleukin-6 (IL-6) is a multifunctional cytokine with important functions in various physiologic processes. Mice lacking IL-6 exhibit multiple phenotypic abnormalities, such as an inadequate immune and acute-phase response, and elevated levels of circulating IL-6 have been found to accompany several pathological conditions. IL-6 binds the nonsignaling IL-6 receptor (IL-6R), which is expressed...
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127 Received August 25, 2014; revised and accepted January 28, 2015. Published online February 20, 2015; doi: 10.1620/tjem.235.127. Correspondence: Takeshi Sato, M.D., Department of Gastroenterology, Yamagata University Faculty of Medicine, 2-2-2 Iida-Nishi, Yamagata, Yamagata 990-9585, Japan. e-mail: [email protected] Treatment with Anti-Interleukin-6 Receptor Antibody Ameliorat...
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Three forms of interleukin-6 (IL-6) have been constructed and stably transfected into human hepatoma cells (HepG2). Wild type IL-6 containing a signal peptide was rapidly secreted as a biologically active protein. IL-6 lacking the signal peptide accumulated within the cytoplasm of transfected cells. Surprisingly, IL-6 carrying a COOH-terminal extension of the amino acids Lys-Asp-Glu-Leu (KDEL) ...
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1,25(OH)(2)D(3) has antiproliferative effects and promotes cell differentiation. This consideration has provided the rationale for studies in subtotally nephrectomized rats showing that 1,25(OH)(2)D(3) interfered with glomerulosclerosis. The cellular mechanisms involved have remained obscure, however. It was the purpose of the present study to assess glomerular structure and cellular compositio...
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ژورنال
عنوان ژورنال: Kidney Research and Clinical Practice
سال: 2016
ISSN: 2211-9132
DOI: 10.1016/j.krcp.2016.10.001